Bunny and the Cisapride, Cleo and the Renal-N

Bunny has had some issues with the Cisapride. He has been on it for five days now.

On the first day, he gave me a scare when he exhibited several rounds of pseudo-UTI and it was only after he defecated a second time that I hypothesized that the pseudo-UTI (with urine droplets) episodes were probably Bunny trying to defecate. Luckily there has been no more episodes of pseudo-UTI since then (fingers crossed).

As for his defecation, he did it right after breakfast on Days 1, 2, 3 and 4. I don’t know if this is the effect of the Cisapride or just our usual home-routine with Lactulose. According to the websites, Cisapride takes 1-2 hours to work. For Bunny, I gave it about 15 mins before his breakfast but his defecation was right after breakfast, so was it the Cisapride doing its job, or our usual Lactulose home routine?

On Day 3, Bunny had abdominal contractions and vomited bile after the Cisapride (before food). It happened again on Day 4 (vomited in the morning and again at night), so the vet advised that I should give the Cisapride together with food. I did that today and there has been no vomiting, but Bunny did not defecate.


It’s hard to gauge the cause of not defecating today. Was it just a random off-day (which sometimes happens) or was it because the Cisapride was given together with food, hence it wasn’t effective?

It’s anyone’s guess.

The website did say this:

Cisapride is given by mouth in the form of a compounded tablet, capsule, or liquid. It may be given with or without food, but if your pet vomits when dosed on an empty stomach, give future doses with food or a treat. Measure liquid forms of this medication carefully.

So I gave it with food today, and until now, there is still no defecation. As prescribed, we are only giving 0.06ml, which is a very low dose.

I’m not sure what we should do tomorrow as it’s a public holiday today and I don’t think the clinic is open today.

That’s the trouble with drugs, I guess. That is why I delayed having to use Cisapride for as long as I could.

My hope is that our home routine of Lactulose etc. still works or helps so that we don’t have to increase the dosage of Cisapride.

Bunny is now a bit reluctant to eat his coconut fiber as well so I have resorted to encapsulating the powder as Bunny is very easily pilled. So, Bunny had his coconut fiber in a capsule this morning.

On another note, Cleo is also now reluctant to eat her Renal-N (which is also a powder). I’ve successfully fed it to her by mixing the powder with some Cindy’s pureed food daily since December 2021 – that was a total miracle. Now, I sometimes have to force-feed her the pureed food laced with Renal-N (luckily it can be done…for now) or I bribe her with some renal kibble mixed with the concoction. Force-feeding pureed food is possible because I don’t have the open her mouth. I just rub it on her teeth or mouth. I cannot use a capsule because Cleo cannot be pilled at all. Pilling involves opening her mouth and she does not allow that at all.

We’ll take it one day at a time, Bunny. Hope there will be poop tomorrow.

Queen Cleo has the whole big bed all to herself now.

Cleo has been on Renal-N since last December. I don’t know whether it works or not because we would have to do a blood test to determine if her creatinine level has decreased. I’m trying to put off the blood test until only when it’s necessary. Her creatinine level was at 273 in December 2021. She is on thrice-weekly 200ml home subcut.

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